| Date | Home | Away | Result |
|---|---|---|---|
| 1/9/25 1:00 PM | Sheffield United | Cardiff City | 0-1 |
| 1/9/25 1:45 PM | Fulham FC | Watford FC | 4-1 |
| 1/9/25 1:45 PM | Everton FC | Peterborough United | 2-0 |
| 1/10/25 1:45 PM | Wycombe Wanderers | FC Portsmouth | 2-0 |
| 1/10/25 2:00 PM | Aston Villa | West Ham United | 2-1 |
| 1/11/25 6:00 AM | Middlesbrough FC | Blackburn Rovers | 0-1 |
| 1/11/25 6:00 AM | Bristol City | Wolverhampton Wanderers | 1-2 |
| 1/11/25 6:00 AM | Birmingham City | Lincoln City | 2-1 |
| 1/11/25 6:15 AM | Liverpool FC | Accrington Stanley | 4-0 |
| 1/11/25 8:00 AM | Leicester City | Queens Park Rangers | 6-2 |
| 1/11/25 9:00 AM | Nottingham Forest | Luton Town | 2-0 |
| 1/11/25 9:00 AM | Norwich City | Brighton and Hove Albion | 0-4 |
| 1/11/25 9:00 AM | Reading FC | Burnley FC | 1-3a.e.t |
| 1/11/25 9:00 AM | Exeter City | Oxford United | 3-1 |
| 1/11/25 9:00 AM | AFC Bournemouth | West Bromwich Albion | 5-1 |
| 1/11/25 9:00 AM | Chelsea FC | FC Morecambe | 5-0 |
| 1/11/25 9:00 AM | Brentford FC | Plymouth Argyle | 0-1 |
| 1/11/25 9:00 AM | AFC Sunderland | Stoke City | 1-2a.e.t |
| 1/11/25 11:45 AM | Leeds United | Harrogate Town FC | 1-0 |
| 1/11/25 11:45 AM | Manchester City | Salford City | 8-0 |
| 1/11/25 12:00 PM | Coventry City | Sheffield Wednesday | 5-4a.PSO |
| 1/12/25 6:00 AM | Hull City A.F.C. | Doncaster Rovers | 5-6a.PSO |
| 1/12/25 6:30 AM | FC Tamworth | Tottenham Hotspur | 0-3a.e.t |
| 1/12/25 9:00 AM | Crystal Palace | Stockport County | 1-0 |
| 1/12/25 9:00 AM | Ipswich Town | Bristol Rovers | 3-0 |
| 1/12/25 9:00 AM | Arsenal FC | Manchester United | 4-6a.PSO |
| 1/12/25 9:00 AM | Newcastle United | Bromley FC | 3-1 |
| 1/12/25 10:30 AM | Southampton FC | Swansea City | 3-0 |
| 1/13/25 1:30 PM | Millwall FC | Dagenham and Redbridge | 3-0 |
| 1/14/25 1:45 PM | Leyton Orient | Derby County | 7-6a.PSO |
| 1/14/25 1:45 PM | Mansfield Town | Wigan Athletic | 0-2 |
| 1/14/25 1:45 PM | Preston North End | Charlton Athletic | 2-1 |